Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
Identifieur interne : 002877 ( Main/Exploration ); précédent : 002876; suivant : 002878Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
Auteurs : E. Sofic [Allemagne] ; P. Riederer [Allemagne] ; H. Heinsen [Allemagne] ; H. Beckmann [Allemagne] ; P. Reynolds [Royaume-Uni] ; G. Hebenstreit [Autriche] ; H. Youdim [Israël]Source :
- Journal of Neural Transmission [ 0300-9564 ] ; 1988-10-01.
Abstract
Summary: Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 255% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched controls. In the cortex (Brodmann area 21), hippocampus, putamen, and globus pallidus there was no significant difference in the levels of iron (III) and total iron. Thus the changes in total iron, iron (III) and the iron (II)/iron (III) ratio in the parkinsonian substantia nigra are likely to be involved in the pathophysiology and treatment of this disorder.
Url:
DOI: 10.1007/BF01244786
Affiliations:
- Allemagne, Autriche, Israël, Royaume-Uni
- Angleterre, Bavière, District de Basse-Franconie, Nottinghamshire
- Nottingham, Wurtzbourg
- Université de Nottingham
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Youdim</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Pharmacology, Rappaport Family Research Institute, Faculty of Medicine, Technion, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neural Transmission</title><title level="j" type="sub">Basic neurosciences and genetics, Parkinson's disease and allied conditions, Alzheimer's disease and related disorders, biological psychiatry</title><title level="j" type="abbrev">J. Neural Transmission</title><idno type="ISSN">0300-9564</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1988-10-01">1988-10-01</date><biblScope unit="volume">74</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="199">199</biblScope><biblScope unit="page" to="205">205</biblScope></imprint><idno type="ISSN">0300-9564</idno></series><idno type="istex">FC024056FDC37B5C8B7AAC717C79D040D5FDA637</idno><idno type="DOI">10.1007/BF01244786</idno><idno type="ArticleID">Art8</idno><idno type="ArticleID">BF01244786</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-9564</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 255% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched controls. In the cortex (Brodmann area 21), hippocampus, putamen, and globus pallidus there was no significant difference in the levels of iron (III) and total iron. Thus the changes in total iron, iron (III) and the iron (II)/iron (III) ratio in the parkinsonian substantia nigra are likely to be involved in the pathophysiology and treatment of this disorder.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Israël</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Bavière</li><li>District de Basse-Franconie</li><li>Nottinghamshire</li></region><settlement><li>Nottingham</li><li>Wurtzbourg</li></settlement><orgName><li>Université de Nottingham</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Sofic, E" sort="Sofic, E" uniqKey="Sofic E" first="E." last="Sofic">E. Sofic</name></region><name sortKey="Beckmann, H" sort="Beckmann, H" uniqKey="Beckmann H" first="H." last="Beckmann">H. Beckmann</name><name sortKey="Heinsen, H" sort="Heinsen, H" uniqKey="Heinsen H" first="H." last="Heinsen">H. 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